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Related Experiment Video

Updated: Feb 26, 2026

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Micro/Nanoscale 3D Bioprinting: A Transformative Way to Modulate Cell/Tissue Growth and Function.

Zijie Meng1,2,3,4, Kang Han2,3,4,5, Xinxin Huang2,3,4

  • 1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|February 24, 2026
PubMed
Summary
This summary is machine-generated.

Micro/nanoscale 3D bioprinting fabricates extracellular matrix (ECM)-like structures for tissue engineering. These engineered tissues show promise for regenerative medicine and advanced in vitro models.

Keywords:
cellular behaviorfunction regulationin vitro modelmicro/nanoscale 3d bioprintingtissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Native tissue extracellular matrix (ECM) exhibits complex micro/nanoscale structures crucial for cellular function and tissue homeostasis.
  • Micro/nanoscale three-dimensional (3D) bioprinting enables the creation of biomimetic structures using cell-laden hydrogels.

Purpose of the Study:

  • To provide a systematic overview of recent advancements in micro/nanoscale 3D bioprinting for living tissue constructs.
  • To emphasize the impact of ECM-like micro/nanoscale architectures on cellular and tissue behavior.
  • To explore applications and future directions in the field.

Main Methods:

  • Review of primary micro/nanoscale bioprinting techniques: light-based, extrusion-based, and jetting-based methods.
  • Analysis of the effects of high-resolution 3D bioprinting processes and induced micro/nanostructures on cell growth.
  • Examination of innovations integrating biomechanical stimuli into bioprinted constructs.

Main Results:

  • Micro/nanoscale 3D bioprinting successfully fabricates ECM-like structures that influence cell growth and behavior.
  • Integration of biomechanical stimuli enhances cell and tissue functionality in engineered constructs.
  • Significant applications in tissue regeneration and the development of in vitro models.

Conclusions:

  • Micro/nanoscale 3D bioprinting is a transformative technology for creating biomimetic tissue constructs.
  • Further research is needed to address challenges and advance towards functional tissue/organ analogs.
  • The field holds significant potential for regenerative medicine and disease modeling.