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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Association between fatty acid profile and normal thyroid hormone with different glucose status
Xin Hu1, Dan Wang2, Yazhuo Liu3
1Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
BMC Endocrine Disorders
|February 24, 2026
Summary
Thyroid hormone levels and fatty acid metabolism show distinct relationships based on glucose status. These findings offer insights into lipid metabolism and cardiovascular disease prevention in individuals with varying glycemic control.
Area of Science:
- Endocrinology
- Metabolic Science
- Clinical Chemistry
Background:
- Thyroid hormone regulation is influenced by glucose and fatty acids.
- Previous research primarily focused on thyroid dysfunction, not normal thyroid hormone levels.
- Understanding these relationships in euthyroid individuals is crucial.
Purpose of the Study:
- To investigate the association between normal thyroid hormone levels and fatty acid metabolism.
- To explore how different glucose statuses (diabetes vs. non-diabetes) modify this relationship.
Main Methods:
- Observational study design.
- Assessment of demographic data, lipid profiles, glycemic status, and thyroid hormones.
- Serum fatty acid profiling using liquid chromatography-mass spectrometry.
Main Results:
- In diabetics, free thyroxine (FT4) negatively correlated with eicosatrienoic acid but positively with arachidonic acid, eicosanoic acid, and alcohol consumption.
- In non-diabetics, FT4 showed negative correlations with palmitic acid, linoleic acid, myristic acid, docosapentaenoic acid, age, and HDL-C, but positive correlations with arachidic acid and palmitoleic acid.
Conclusions:
- The interplay between normal thyroid hormone and fatty acid levels varies significantly with glucose status.
- Findings enhance understanding of serum fatty acid profiles in different glycemic states.
- Provides clinical data for managing lipid disorders and cardiovascular disease.
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