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Related Concept Videos

Hair Cells01:22

Hair Cells

45.8K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
45.8K
The Cochlea01:13

The Cochlea

51.7K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Unrenewable Cells00:50

Unrenewable Cells

3.0K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
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Auditory Pathway01:15

Auditory Pathway

7.7K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.7K

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Related Experiment Video

Updated: Feb 26, 2026

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells
05:55

Dextran Labeling and Uptake in Live and Functional Murine Cochlear Hair Cells

Published on: February 8, 2020

8.0K

Two-tone suppression in cochlear hair cells.

P M Sellick1, I J Russell

  • 1Ethology and Neurophysiology Group, Department of Biology, University of Sussex, Brighton BN1 9QG, U.K.

Hearing Research
|February 25, 2026
PubMed
Summary

Two-tone suppression, previously observed at the auditory nerve, also occurs in inner hair cell receptor potentials. This finding reveals a new level at which auditory processing occurs in the cochlea.

Area of Science:

  • Auditory Neuroscience
  • Neurophysiology
  • Sensory Biology

Background:

  • Two-tone suppression is a known phenomenon in auditory processing.
  • It has been previously documented at the auditory nerve level.

Purpose of the Study:

  • To investigate the occurrence of two-tone suppression in inner hair cells.
  • To determine if this phenomenon is present at the receptor potential level in the cochlea.

Main Methods:

  • Electrophysiological recordings from single inner hair cells.
  • Experiments conducted on the first turn of the guinea pig cochlea.

Main Results:

  • Two-tone suppression was observed in the receptor potential of single inner hair cells.

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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research
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Author Spotlight: Advancements in Cultivating Mouse Hair Cells for Auditory Research

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Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
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Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse

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Related Experiment Videos

Last Updated: Feb 26, 2026

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Postsynaptic Recordings at Afferent Dendrites Contacting Cochlear Inner Hair Cells: Monitoring Multivesicular Release at a Ribbon Synapse
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  • This indicates the phenomenon extends to the hair cell level.

    • Conclusions:

    • Two-tone suppression occurs not only at the auditory nerve but also within the inner hair cells.
    • This suggests a more complex processing of auditory information at the receptor level than previously understood.