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Prolonged intermittent high-volume hemofiltration in severe septic shock
Rodrigo A Sepúlveda1,2, Cristián Juanet1,2, Juan P Huidobro1,2
1Department of Nephrology, School of Medicine, Pontificia Universidad Católica de Chile, Red de Salud UC-Christus, Santiago, Chile.
The International Journal of Artificial Organs
|February 25, 2026
Summary
Prolonged intermittent high-volume hemofiltration (HVHF) may help manage severe septic shock. This therapy showed potential benefits, particularly for women and surgical patients, by supporting hemodynamics and modulating the immune system.
Area of Science:
- Critical Care Medicine
- Nephrology
- Intensive Care
Background:
- Septic shock is a life-threatening condition requiring advanced interventions.
- High-volume hemofiltration (HVHF) is explored for hemodynamic support and immunomodulation in severe septic shock.
Purpose of the Study:
- To evaluate the response to HVHF in severe septic shock patients.
- To identify factors associated with mortality in this patient cohort.
Main Methods:
- Retrospective cohort study of 63 severe septic shock patients receiving HVHF.
- Analysis of patient demographics, clinical data, and outcomes.
Main Results:
- Mortality was associated with male sex, medical pathology, chronic critical illness, elevated SOFA scores, and high norepinephrine doses.
- HVHF within 24 hours of surgery correlated with lower mortality (p=0.025).
- Actual mortality (73%) was lower than predicted by SOFA scores (80%-90%).
Conclusions:
- HVHF may facilitate management of severe septic shock, especially in women and surgical patients.
- The therapy offers hemodynamic support and immunomodulation, potentially improving prognosis.
- HVHF allows time for infection control and better patient outcomes.
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