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Bi-Clonal (CD4+ and CD8+) T Cell Large Granular Lymphocytic Leukemia (T LGLL) in an Asymptomatic Young Patient

Kusum Gupta1, Khaliqur Rahman1, Ruchi Gupta1

  • 1Department of Hematology, SGPGIMS, Lucknow, Uttar Pradesh, India.

International Journal of Laboratory Hematology
|February 25, 2026
PubMed
Abstract

No abstract available in PubMed .

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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