Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

95
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
95
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.4K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spontaneous closure of secondary full-thickness macular hole following pars plana vitrectomy for rhegmatogenous retinal detachment: a case report and literature review.

Journal of medical case reports·2026
Same author

Activation of Nrf2 with natural flavonoids and mesenchymal stromal/stem cells: mechanisms and therapeutic potential for inflammatory diseases.

Stem cell research & therapy·2026
Same author

Delivered baicalein immunomodulatory hydrogel with dual properties of pH-responsive and anti-infection orchestrates pro-regenerative response of macrophages for enhanced hypertrophic scars therapy.

Materials today. Bio·2025
Same author

Natural small molecules synergize mesenchymal stem cells for injury repair in vital organs: a comprehensive review.

Stem cell research & therapy·2024
Same author

hsa_circ_0072387 Suppresses Proliferation, Metastasis, and Glycolysis of Oral Squamous Cell Carcinoma Cells by Downregulating miR-503-5p.

Cancer biotherapy & radiopharmaceuticals·2020
Same author

Construction of Injectable Self-Healing Macroporous Hydrogels via a Template-Free Method for Tissue Engineering and Drug Delivery.

ACS applied materials & interfaces·2018

Related Experiment Video

Updated: Feb 26, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.1K

Recent Progress in Selenium Nanomedicines for Ocular Diseases.

Bo Jiang1, Liyue Zhang1, Nan Hong1

  • 1Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, People's Republic of China.

International Journal of Nanomedicine
|February 25, 2026
PubMed
Summary

Selenium nanoparticles (SeNPs) offer a promising, safer alternative for treating eye diseases like diabetic retinopathy and cataracts, showing enhanced bioavailability and reduced toxicity in preclinical studies.

Keywords:
nanotechnologyocular diseasesoxidative stressseleniumselenium nanoparticles

More Related Videos

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.4K
Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy
06:00

Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy

Published on: May 27, 2022

3.1K

Related Experiment Videos

Last Updated: Feb 26, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

1.1K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.4K
Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy
06:00

Biological Samples Preparation for Speciation at Cryogenic Temperature using High-Resolution X-Ray Absorption Spectroscopy

Published on: May 27, 2022

3.1K

Area of Science:

  • Nanomedicine
  • Ophthalmology
  • Materials Science

Background:

  • Vision impairment is a major global health issue, with cataracts, AMD, glaucoma, and DR being leading causes in the elderly.
  • Current ophthalmic drugs suffer from poor bioavailability and toxicity, necessitating novel therapeutic strategies.
  • Selenium (Se) has known ocular benefits but faces limitations in therapeutic window and bioavailability.

Purpose of the Study:

  • To review the potential of selenium nanoparticles (SeNPs) as nanomedicines for ocular diseases.
  • To analyze the synergistic effects of SeNPs' intrinsic bioactivities and drug delivery capabilities.
  • To assess the clinical translation potential of Se-based nanomedicines for complex eye conditions.

Main Methods:

  • Comprehensive literature search of PubMed, Scopus, Web of Science, and Google Scholar.
  • Analysis of preclinical and early clinical data on SeNPs for various ocular pathologies.
  • Evaluation of SeNP mechanisms, including antioxidant and anti-angiogenic properties.

Main Results:

  • SeNPs demonstrate enhanced bioavailability, reduced toxicity, and targeted delivery potential compared to conventional Se therapies.
  • Strong preclinical evidence supports SeNPs in models of diabetic retinopathy, neovascularization, keratitis, and cataracts.
  • A Phase I trial of quantum dots (QDs) in retinitis pigmentosa showed tolerability and visual function improvements.

Conclusions:

  • SeNPs represent versatile nanoplatforms with multi-mechanistic bioactivities for treating complex ocular diseases.
  • Se-based nanomedicines show significant potential for clinical translation in ophthalmology.
  • Further research is crucial to optimize SeNP design and facilitate their safe clinical application.