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Efficacy of Anti-Adhesive Barriers on Outcomes Following Pediatric Abdominal Surgery: A Systematic Review and

Khang Duy Ricky Le1,2,3, Shasha Haycock1,2,4, Annie Jiao Wang1,2

  • 1Department of Surgery Northeast Health Wangaratta Wangaratta Victoria Australia.

Health Science Reports
|February 25, 2026
PubMed

Insights

Anti-adhesive barriers may help prevent adhesional small bowel obstruction (ASBO) in pediatric abdominopelvic surgery. However, current evidence is limited by study bias and heterogeneity, necessitating further research.

Area of Science:

  • Pediatric Surgery
  • Gastrointestinal Surgery
  • Surgical Innovation

Background:

  • Adhesional small bowel obstruction (ASBO) is a significant concern following pediatric abdominopelvic surgery.
  • The effectiveness of anti-adhesive barriers in preventing ASBO in children remains unclear.

Purpose of the Study:

  • To review the current literature on the efficacy of anti-adhesive barriers in preventing ASBO in pediatric patients.
  • To evaluate the utility of these barriers in pediatric populations undergoing abdominopelvic surgery.

Main Methods:

  • A systematic literature search was conducted across multiple databases including Embase, Medline, Cochrane Central, and WHO ICTRP.
  • Key outcome measures included ASBO, overall complications, re-operation rates, and surgical site infections.

Main Results:

  • Analysis of two studies (912 patients) indicated that anti-adhesive barriers significantly reduced the risk of ASBO (OR 0.39).
  • Insufficient evidence exists to support a benefit in reducing overall postoperative complications or surgical site infections.

Conclusions:

  • Anti-adhesive barriers show potential for preventing ASBO in pediatric open abdominopelvic surgery.
  • However, findings are limited by moderate-to-high risk of bias, small sample sizes, and clinical heterogeneity, requiring further prospective validation.
Abstract

Keywords:
abdominopelvic surgeryadhesionsanti‐adhesive barriersbowel obstructionlaparoscopypediatric surgeryseprafilm

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