Improving Single Maintenance and Reliever Therapy for Patients Admitted for Asthma Exacerbation

Katherine A Pumphrey1, Jessica K Hart2, Joseph J Zorc2,3

  • 1From the Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass.

Pediatric Quality & Safety
|February 25, 2026
PubMed

Insights

Single maintenance and reliever therapy (SMART) is now recommended for children with persistent asthma. This quality improvement project successfully increased SMART prescriptions at discharge for pediatric asthma patients, improving equitable care.

Area of Science:

  • Pediatric pulmonology
  • Quality improvement science
  • Health equity research

Background:

  • Single maintenance and reliever therapy (SMART) is guideline-recommended for school-aged children with poorly controlled persistent asthma in the US.
  • Pediatric inpatient providers are crucial for prescribing SMART to high-risk asthma patients.
  • Existing SMART prescription rates at discharge were suboptimal (17%), necessitating targeted interventions.

Purpose of the Study:

  • To increase the proportion of SMART prescriptions at discharge for eligible pediatric asthma patients from 17% to 40% by September 2023.
  • To ensure equitable improvements in SMART prescribing across diverse patient populations (payor type, race, Child Opportunity Index).
  • To address key drivers of SMART prescription: prescriber familiarity, culture, decision support, and logistics.

Main Methods:

  • A quality improvement project utilizing 10 Plan-Do-Study-Act cycles.
  • Interventions focused on education and clinical decision support to address identified drivers.
  • Inclusion criteria: pediatric patients with inhaled controller medication, and ≥2 asthma exacerbation-related hospitalizations/ER visits within 12 months.

Main Results:

  • SMART prescription at discharge increased from 17% to 38% and was sustained for 19 months.
  • The increase was observed across demographic strata, including Black patients, those with government insurance, and those with low Child Opportunity Index.
  • The project involved 312 hospital encounters for 215 unique pediatric patients between January 2021 and December 2023.

Conclusions:

  • Quality improvement methodology effectively increased SMART prescriptions at discharge for pediatric asthma exacerbation.
  • The interventions demonstrated success in reducing disparities in asthma care.
  • Sustained improvements in SMART prescribing contribute to better asthma management in pediatric populations.
Abstract

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