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Patient Perspectives on Artificial Intelligence-Based Diabetic Retinopathy Screening at an Urban US Medical Center
Zainab Rustam1, Yangyiran Xie2, Jose Amezcua Moreno1
1Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|February 25, 2026
Summary
Patients are comfortable with artificial intelligence (AI) for diabetic retinopathy (DR) screening but prefer physician oversight. Most do not believe AI can replace a doctor, highlighting a gap in understanding autonomous AI
Area of Science:
- Ophthalmology
- Artificial Intelligence
- Medical Imaging
Background:
- Diabetic retinopathy (DR) screening is crucial for preventing vision loss in diabetes patients.
- Fully autonomous artificial intelligence (AI) offers potential to improve access and efficiency in DR screening.
- Patient perspectives are essential for the successful implementation of novel healthcare technologies like AI in DR screening.
Purpose of the Study:
- To explore patient perspectives on the use of AI in diabetic retinopathy (DR) screening.
- To assess patient awareness, trust, perceived efficiency, and overall receptivity towards AI in eye care.
- To understand patient preferences regarding physician interaction and oversight in AI-assisted DR screening.
Main Methods:
- A survey was administered to 100 adults with diabetes undergoing DR screening with a handheld AI fundus camera.
- Participants responded to questions on AI awareness, trust, efficiency, personal interaction preferences, and overall acceptance.
- Responses were analyzed and stratified by sociodemographic and neighborhood characteristics.
Main Results:
- Most participants (78%) were aware of AI in healthcare, but only 46% knew of its application to eye disease.
- While 76% were comfortable with AI in eye exams and 92% satisfied, 83% preferred physician oversight.
- Only 31% believed AI could replace a doctor visit, with 94% affirming doctors' ultimate diagnostic responsibility.
Conclusions:
- Patients generally accept AI as part of DR screening but value physician supervision.
- A significant gap exists between the concept of fully autonomous AI screening and patient expectations of physician involvement.
- Implementation strategies for autonomous AI DR screening must address patient understanding and preferences for physician roles.

