Related Experiment Video

Updated: Feb 26, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

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Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancer

Yujun Shuai1,2, Haojie Huang1,2

  • 1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Journal of the National Cancer Center
|February 25, 2026
PubMed

Insights

Prostate cancer cells develop resistance to therapies like ADT and ARSI by altering gene expression and cell identity. New strategies targeting these adaptive mechanisms are crucial for effective advanced prostate cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Prostate cancer is a leading cause of cancer mortality in men globally.
  • Therapeutic resistance in prostate cancer poses a significant clinical challenge.
  • Understanding resistance mechanisms is vital for developing new treatment strategies.

Purpose of the Study:

  • To review the relationship between transcriptional/epigenetic reprogramming, lineage plasticity, and treatment resistance in prostate cancer.
  • To explore how prostate cancer cells evade therapies like androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI).
  • To discuss novel therapeutic strategies targeting these resistance mechanisms.

Main Methods:

  • Review of current scientific literature on prostate cancer biology and treatment resistance.
  • Analysis of the roles of transcriptional reprogramming and epigenetic modifications.
  • Examination of lineage plasticity as a driver of therapeutic evasion.

Main Results:

  • Prostate cancer cells exhibit adaptive resistance through transcriptional and epigenetic changes.
  • Lineage plasticity allows cancer cells to alter identity and evade treatment.
  • Key transcription factors and epigenetic regulators (DNA methylation, histone modification, non-coding RNAs) are implicated in resistance.

Conclusions:

  • Targeting reprogramming and plasticity mechanisms offers promising therapeutic avenues.
  • Combination therapy and precision medicine are essential for treating advanced prostate cancer.
  • Further research into these adaptive strategies is needed to overcome treatment resistance.
Keywords:
Lineage plasticityProstate cancerTherapy resistanceTranscriptional and epigenetic reprogramming

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