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Antidiabetic Polyphenolic Compounds Including Two Unique Dimers Featuring a 6/6/7/6/5 Ring System from the Roots of
Xu Zhang1, Jiang Li1, Xiao-Yun Yan1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
Two unique polyphenolic compounds featuring a 6/6/7/6/5 fused skeleton, sotodisoflavanones A and B (1 and 2), and two novel 2-arylbenzofuran dimers shandougenines C and D (3 and 4) were isolated from the roots of Sophora tonkinensis. Their structures were elucidated through spectroscopic analysis and quantum chemical calculations. Compounds 1 and 5-7 showed significant PTP1B inhibition (IC50 = 2.70 ± 0.50, 0.88 ± 0.17, 2.70 ± 0.50, 1.90 ± 0.40 μM, respectively) and enhanced insulin sensitivity by promoting HepG2 cell glucose consumption.
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