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Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Related Experiment Video

Updated: Feb 26, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Layer-Specific Strain Analysis for Detecting Subclinical Cardiac Dysfunction in Systemic Lupus Erythematosus.

Mert Gürsoy1, Murat Kazım Ersanlı1, Hasan Ali Barman1

  • 1Cerrahpasa Institute of Cardiology, Department of Cardiology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|February 25, 2026
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) patients show subclinical heart dysfunction, particularly in the left ventricle's endocardial layer, detected by speckle tracking echocardiography (STE). This early cardiac involvement correlates with disease activity, highlighting STE's diagnostic value.

Keywords:
global longitudinal strainlayer‐specific strainsystemic lupus erythematosus

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Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Cardiac involvement in Systemic Lupus Erythematosus (SLE) is often undetected, leading to underdiagnosis.
  • Global Longitudinal Strain (GLS) is known to be impaired in SLE, but layer-specific data is limited.
  • Understanding subclinical myocardial dysfunction is crucial for managing SLE patients.

Purpose of the Study:

  • To evaluate left and right ventricular function in SLE patients using Speckle Tracking Echocardiography (STE).
  • To specifically assess layer-specific left ventricular (LV) strain and its correlation with SLE disease activity.

Main Methods:

  • A cross-sectional study involving 43 SLE patients and 40 healthy controls.
  • Conventional echocardiography and STE were performed on all participants.
  • Layer-specific LV GLS (endocardial, mid-myocardial, epicardial) and RV free wall strain were measured and correlated with SLEDAI-2K scores.

Main Results:

  • STE revealed significantly reduced LV endocardial and mid-myocardial GLS in SLE patients compared to controls.
  • Right ventricular (RV) free wall strain was also significantly lower in SLE patients.
  • LV endocardial strain showed a strong positive correlation with the SLEDAI-2K disease activity score.

Conclusions:

  • Speckle tracking echocardiography effectively detects early, subclinical biventricular myocardial impairment in SLE patients.
  • Systolic dysfunction in SLE is primarily evident at the endocardial layer of the left ventricle.
  • STE is a valuable tool for assessing cardiac involvement and its association with disease activity in SLE.