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Updated: Feb 26, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Transgender individuals and cardiovascular risk: what should the cardiologist know]
Antonia Mannarini1, Maria Teresa Manes2, Giuseppe Ciliberti3
1U.O.C. Cardiologia Ospedaliera, A.O.U. Policlinico, Bari.
Abstract:
Cardiovascular risk estimation in transgender people is an emerging research area with significant clinical implications. Healthcare for transgender people is challenging, as it encompasses the impact of hormone therapies, social inequalities, and chronic stress associated with potential discrimination. In fact, these factors may differently influence cardiovascular risk as compared to the cisgender population, although current evidence is still limited. The aim of this paper was to provide an overview of current knowledge about cardiovascular disease in transgender individuals in order to promote an evidence-based approach for this population and, finally, health equality in cardiovascular disease management.
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