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Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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High-Resolution Comparison of Bacterial Conjugation Frequencies
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Cardiovascular Risk in Psoriasis Compared With Atopic Dermatitis: The Shizuoka Kokuho Database.

Kanako Takeda1, Masato Takeuchi1, Hideo Hashizume1,2

  • 1Shizuoka Graduate University of Public Health, Shizuoka, Japan.

The Journal of Dermatology
|February 25, 2026
PubMed
Summary

This study found no increased cardiovascular event risk for psoriasis patients compared to atopic dermatitis patients in Japan. Psoriasis (Ps) and major adverse cardiovascular events (MACE) risk was similar in this Asian population.

Keywords:
atopic dermatitiscardiovascular riskcohort studyobservational studypsoriasis

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Area of Science:

  • Dermatology
  • Cardiology
  • Epidemiology

Background:

  • Psoriasis is a chronic inflammatory skin disease linked to cardiovascular disease in Western populations.
  • Evidence on cardiovascular risk in Asian psoriasis patients is limited.

Purpose of the Study:

  • To evaluate the risk of major adverse cardiovascular events (MACE) in Japanese patients with psoriasis compared to those with atopic dermatitis (AD).

Main Methods:

  • A cohort study used the Shizuoka Kokuho Database (Japan) from April 2012 to September 2022.
  • Patients aged ≥40 years newly diagnosed with psoriasis or AD were included.
  • Propensity score matching balanced groups; MACE (myocardial infarction or stroke) hospitalization was the primary outcome.

Main Results:

  • After matching (n=2208 per group), MACE incidence was 2.7% in both psoriasis and AD groups over a median 4.5-year follow-up.
  • Hazard ratio for MACE was 0.96 (95% CI 0.67-1.38; p=0.84), with no significant difference in myocardial infarction or stroke risk.
  • Results remained consistent across subgroups and sensitivity analyses.

Conclusions:

  • No excess risk of major adverse cardiovascular events was observed in Japanese patients with psoriasis compared to those with atopic dermatitis.
  • The cardiovascular risk specifically attributable to psoriasis may be limited in the Japanese population.