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Quaternized Thiomers for Antibacterial Activity and Hyperinflammation Mitigation.

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A novel quaternary thiolated polymer (QTP) effectively combats drug-resistant bacteria and biofilms. This broad-spectrum antibacterial agent also reduces inflammation and promotes wound healing, offering a promising solution for challenging infections.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Infectious Diseases

Background:

  • Rising infections and limited antibacterial options necessitate new broad-spectrum treatments.
  • Superbugs form resilient biofilms, complicating infection control.
  • Chitosan derivatives show promise, but synergistic modifications are underexplored.

Purpose of the Study:

  • To synthesize and evaluate a novel quaternary thiolated polymer (QTP).
  • To investigate the synergistic antibacterial and anti-biofilm properties of QTP.
  • To assess QTP's efficacy in a wound infection model.

Main Methods:

  • Quaternary thiolated polymer (QTP) synthesized from HTCC and thioglycolic acid.
  • Broad-spectrum antibacterial activity tested against resistant bacteria.
  • Antioxidant, toxicity, and biofilm inhibition assays performed.
  • Efficacy evaluated in a murine superficial wound infection model.

Main Results:

  • QTP demonstrated broad-spectrum activity against Gram-positive and Gram-negative bacteria.
  • The polymer exhibited antioxidant properties and low toxicity.
  • QTP significantly reduced bacterial biofilms (>99.9%).
  • In vivo, QTP eradicated MRSA and promoted dermal healing.

Conclusions:

  • QTP offers a synergistic combination of quaternization and thiolation.
  • The developed polymer presents a potent therapeutic candidate against resistant bacterial infections.
  • QTP shows potential for treating complex wound infections.