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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

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Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.

Valerie Karl¹, Ludvig D Bjørndal^2,3, Eira R Aksnes^2,4

¹PROMENTA Research Center, Department of Psychology, University of Oslo, Blindern, PO Box 1094, 0317, Oslo, Norway. valerie.karl@psykologi.uio.no.

European Child & Adolescent Psychiatry

|February 25, 2026

Summary

Internalizing problems in adolescents are linked to specific brain network connectivity. Feelings of worthlessness, guilt, sadness, and fearfulness show distinct associations with default, frontoparietal, and salience networks.

Keywords:

ABCD Functional connectivity Internalizing problems Network analysis Symptom networks Youth

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Published on: March 21, 2019

Area of Science:

Neuroscience
Developmental Psychology
Child Psychiatry

Background:

Internalizing problems in youth are common but heterogeneous.
Previous research linked internalizing problems to default (DN), frontoparietal (FP), and salience (SA) brain networks.
Understanding symptom-specific brain connectivity is crucial due to comorbidity.

Purpose of the Study:

To investigate symptom-specific associations between internalizing problems and brain functional connectivity in adolescents.
To explore sex and timing-specific differences in these links.

Main Methods:

Utilized a large population-based sample of adolescents (N=2426).
Employed an integrated network modeling approach.
Analyzed self-reported internalizing symptoms and functional connectivity data.

Main Results:

Negative associations found between worthlessness/guilt and default network (DN) within-network connectivity.
Positive associations found between fearfulness and frontoparietal network (FP) within-network connectivity.
Sadness and fearfulness positively associated with DN-salience network (SA) between-network connectivity.

Conclusions:

Internalizing problems in youth are associated with specific patterns of brain functional circuitry.
Findings highlight a complex interplay between internalizing symptoms and brain networks.
Early brain connectivity may predict later internalizing symptoms.