Related Experiment Video

Updated: Feb 26, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.6K

18 F-FDG PET/CT Demonstrates Significant Response in Anaplastic Thyroid Carcinoma Treated With Combined Immunotherapy

Yamini Dharmashaktu1, Sameer Rastogi2, Ritwik Wakankar1

  • 1Department of Nuclear Medicine.

Clinical Nuclear Medicine
|February 25, 2026
PubMed

Insights

Anaplastic thyroid carcinoma (ATC) treatment with Pembrolizumab and Lenvatinib showed significant response. 18F-FDG PET/CT imaging confirmed a near complete metabolic response in this aggressive cancer case.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Anaplastic thyroid carcinoma (ATC) is a rare, aggressive thyroid cancer with poor prognosis.
  • Conventional treatments offer limited efficacy for ATC.
  • Targeted therapy and immunotherapy present emerging treatment options for ATC.

Purpose of the Study:

  • To report a case of anaplastic thyroid carcinoma (ATC) treated with Pembrolizumab and Lenvatinib.
  • To evaluate the therapeutic response using 18F-FDG PET/CT imaging.

Main Methods:

  • A 51-year-old female patient with biopsy-proven ATC was treated with Pembrolizumab and Lenvatinib.
  • 18F-FDG PET/CT imaging was performed for treatment response assessment.

Main Results:

  • The patient presented with extensive locoregional disease and pulmonary metastases.
  • Post-treatment 18F-FDG PET/CT revealed a near complete metabolic response.

Conclusions:

  • Pembrolizumab and Lenvatinib demonstrate potential efficacy in managing advanced anaplastic thyroid carcinoma.
  • 18F-FDG PET/CT is a valuable imaging modality for monitoring treatment response in ATC.
Keywords:
anaplastic thyroid carcinomalenvatinibnear complete metabolic responsepembrolizumab

More Related Videos

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography09:34

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

3.9K
Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment10:33

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment

Published on: April 25, 2025

1.2K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K