Old Drug, New Opportunity: Drug Repurposing in Cardiovascular Diseases

Area of Science:

• Pharmacology
• Cardiovascular Medicine
• Drug Discovery

Background:

• Cardiovascular disease (CVD) presents a significant global health challenge.
• Development of novel CVD therapeutics is hindered by high costs and long timelines.
• Drug repurposing is a promising strategy to accelerate therapeutic development for CVD.

Purpose of the Study:

• To systematically evaluate the repurposing potential of existing drugs for cardiovascular disease (CVD).
• To elucidate potential mechanisms, efficacy, and safety profiles of repurposed CVD drugs.
• To discuss methodologies for identifying promising drug repurposing candidates for CVD.

Main Methods:

• Systematic review of currently available drugs for CVD repurposing potential.
• Evaluation of drug mechanisms, efficacy, and safety profiles.
• Discussion of methodologies for identifying drug repurposing candidates.

Main Results:

• Drug repurposing can yield safer, more efficacious, and cost-effective CVD alternatives.
• Identified methodologies facilitate the discovery of promising repurposing candidates.
• Explored translational and commercial barriers in CVD drug repurposing.

Conclusions:

• Drug repurposing offers a viable strategy to address unmet needs in cardiovascular disease (CVD) treatment.
• Integrating precision medicine, AI-driven discovery, and collaboration can overcome repurposing challenges.
• Repurposed drugs can bridge the gap between clinical needs and drug development pipelines for CVD.