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Longitudinal Studies

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...

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Updated: Feb 27, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Published on: December 27, 2010

Longitudinal molecular network analysis in Guangxi: implications for HIV control.

Xianwu Pang¹, Kailing Tang, Qin He

¹Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi, China.

AIDS (London, England)

|February 25, 2026

Summary

Guangxi

Keywords:

HIV Intervention effects Molecular network Transmission Transmission network

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Last Updated: Feb 27, 2026

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

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Published on: December 27, 2010

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV

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Published on: March 5, 2022

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Area of Science:

Epidemiology
Molecular Epidemiology
Public Health

Background:

Guangxi, China, experiences a persistent HIV epidemic.
Heterosexual transmission and an aging population are key drivers.
Understanding HIV transmission dynamics is crucial for effective control.

Purpose of the Study:

To analyze the molecular network topology and dynamics of HIV transmission in Guangxi.
To provide insights for targeted HIV control strategies in the region.

Main Methods:

Collected 9,751 HIV pol gene samples from 2005-2024.
Constructed molecular networks using TN93 genetic distance.
Calculated network indicators across four time periods.

Main Results:

HIV epidemic in Guangxi is aging, with individuals aged ≥50 years increasing significantly.
Heterosexual transmission became the predominant mode.
Network structure shifted from centralized to fragmented, indicating reduced superspreading and network expansion.

Conclusions:

HIV molecular network complexity and intensity have decreased in Guangxi.
Findings support targeted interventions for older, less-educated farmers.
Enhanced monitoring is needed for specific subgroups.