Related Experiment Video
Updated: Feb 28, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
pH-responsive emulsification and stability of high internal phase emulsions stabilized by octenyl succinic acid soy
Liwen Xin1, Shengnan Wang2, Shujie Shi1
1College of Food Science and Technology, Bohai University, Jinzhou 121013, China.
Abstract:
Octenyl succinic anhydride-modified soy hull polysaccharides (OSHP) were synthesized to examine how pH influences their structure and emulsifying performance. Succinylation markedly improved interfacial activity by dissociating polysaccharide aggregates and introducing hydrophobic alkyl groups. Under acidic conditions (pH 2.0-3.0), enhanced molecular flexibility promoted balanced hydrophilic-lipophilic interactions, reducing interfacial tension to 4.81-10.72 mN/m after 180 min. At pH levels of 4.0-6.0, partial hydrolysis of ester linkages weakened interfacial stabilization. At alkaline pH (7.0-9.0), increased surface charge reduced interfacial affinity, while carbonyl dissociation facilitated internal hydrogen bond rearrangement. Correspondingly, high internal phase emulsions (HIPEs) formed at pH 7.0-9.0 exhibited initial viscosities of 23.84-31.42 Pa·s. These findings provide new insight into the design of esterified polysaccharide-stabilized HIPEs and offer a practical strategy for developing pH-responsive emulsion systems with tunable interfacial and rheological properties.
Related Concept Videos
Surface Active Agents
Esters to Carboxylic Acids: Saponification
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...
Colloids
Micelles

