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The role of lymphangiogenesis in cardiovascular disease

Yingying Zhang1, Danyan Xu1, Li Shen1

  • 1Department of Internal Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Life Sciences
|February 25, 2026
PubMed

Insights

Lymphangiogenesis, the formation of new lymphatic vessels, plays a protective role in cardiovascular diseases (CVDs) by managing fluid balance and inflammation. Further research into its mechanisms could lead to new CVD treatments.

Area of Science:

  • Cardiovascular Science
  • Lymphatic Biology
  • Medical Research

Background:

  • Lymphatic vessels are crucial for fluid balance, immune response, lipid absorption, and hormone regulation.
  • Growing evidence links lymphangiogenesis (new lymphatic vessel formation) to cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review and synthesize the current understanding of the relationship between lymphangiogenesis and CVDs.

Main Methods:

  • This study is a review of existing literature.
  • It synthesizes findings from various research studies on lymphangiogenesis and CVDs.

Main Results:

  • Lymphatic vessels help reduce heart swelling, decrease persistent inflammation, lower cholesterol buildup, and manage protein secretion.
  • These functions highlight the protective role of lymphangiogenesis in cardiovascular health.

Conclusions:

  • Lymphangiogenesis presents a promising new therapeutic avenue for treating cardiovascular diseases.
  • Further investigation into the molecular pathways governing lymphangiogenesis is essential for therapeutic development.
Abstract

Keywords:
Cardiovascular diseases (CVDs)EdemaInflammationLymphangiogenesisLymphatic vessels

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