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Updated: Feb 28, 2026

Visualizing Methane-Cycling Microbial Dynamics in Coastal Wetlands
Published on: January 31, 2025
Advances in denitrifying anaerobic methane Oxidation: Emerging insights into the physiology and metabolism
Ruiyan Lang1, Yueran Hao1, Mingyu Guo1
1School of Ecology and Environment, Zhengzhou University, Zhengzhou 450001, China.
Abstract:
Denitrifying anaerobic methane oxidation (DAMO) is a unique microbial process in which methane (CH4) serves as an electron donor for nitrate (NO3-) or nitrite (NO2-) reduction, playing a role in coupled nitrogen-carbon cycling. This review summarizes recent advances that revise the classical understanding of DAMO microorganisms. DAMO bacteria exhibit diverse nitrogen metabolic capabilities, including intracellular oxygen production, complete denitrification, and involvement in both nitrous oxide (N2O) production and reduction through synergistic interactions. For DAMO archaea, we review the reverse methanogenesis pathway and highlight emerging metabolic strategies such as extracellular electron transfer (EET), dissimilatory nitrate reduction to ammonium (DNRA), and acetate production. In addition, we discuss the role of large extrachromosomal genetic elements (ECEs), including Borgs and mini-Borgs, in expanding host metabolic functions related to CH4 oxidation, electron transport, and nitrogen metabolism. This review provides comprehensive understanding on the diverse physiology and flexible metabolism of DAMO microorganism.
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