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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Development of a bioactive hydroxyapatite concentration gradient double hydroxyapatite/titanium dioxide coating on
Sang-Hyun Cho1,2, Min-Yong Lee1, Ji-Eun Kim1
1Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry.
A novel hydroxyapatite (HA)-coated titanium dioxide (TiO2) block bone with a gradient HA layer was developed for bone grafting. This new material demonstrates superior strength and bone formation potential, offering a promising alternative to traditional bone grafts.
Area of Science:
- Biomaterials Science
- Dental Implantology
- Regenerative Medicine
Background:
- Increasing demand for bone graft procedures to enhance bone volume for dental implant placement.
- Block bone grafting is a preferred method for horizontal and vertical bone augmentation.
- Need for bone graft materials with improved physical and biological properties.
Purpose of the Study:
- To develop a novel hydroxyapatite (HA)-coated titanium dioxide (TiO2) core block bone.
- To engineer an HA concentration gradient layer for enhanced mechanical properties and bone integration.
- To evaluate the efficacy of the developed block bone as a substitute for conventional grafts.
Main Methods:
- Fabrication of a TiO2 core block bone with a double-layered HA coating featuring a concentration gradient.
- Characterization of the HA concentration gradient using scanning electron microscopy/energy-dispersed X-ray spectroscopy.
- Assessment of coating stability via scratch testing and evaluation of bone formation using alizarin red S staining.
Main Results:
- Confirmation of the HA concentration gradient and its stability on the TiO2 core.
- Demonstration of superior compressive strength and wear resistance due to the HA gradient.
- Evidence of retained bone formation on the HA gradient layer, outperforming a single-layer HA coating.
Conclusions:
- The developed double-layered HA gradient TiO2 block bone exhibits favorable physical and biological characteristics.
- The material shows significant potential as an effective substitute for conventional block bone grafts in augmentation procedures.
- This novel biomaterial could advance bone regeneration techniques in implant dentistry.
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