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Related Concept Videos

Brain Imaging01:14

Brain Imaging

797
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
797

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Related Experiment Video

Updated: Feb 28, 2026

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
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Localizing Sports-related Concussion and Characterizing Recovery Trajectories with Multimodal Brain Imaging.

Natalie M Bell1, James M Holcomb1, Sarah G Holmes1

  • 1From the Advanced Neuroscience Imaging Research (ANSIR) Lab, Department of Radiology (N.M.B., J.M.H., S.G.H., M.R.B., C.J., F.F.U., J.A.M., E.M.D.), Biomedical Engineering (J.M.H., F.F.U., J.A.M., E.M.D.), Psychiatry (M.C.), Neurological Surgery (M.C.), Pediatrics (A.T., M.S.) and Neurology (A.T., M.S.), University of Texas Southwestern Medical Center, Dallas, TX, USA.

AJNR. American Journal of Neuroradiology
|February 25, 2026
PubMed
Summary
This summary is machine-generated.

This study used multimodal brain imaging to track concussion recovery in a teen soccer player. Findings show brain changes like reduced blood flow and altered brain activity post-concussion, highlighting imaging

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Area of Science:

  • Neuroscience
  • Sports Medicine
  • Radiology

Background:

  • Sports-related concussions are common in high school athletes.
  • Understanding the neurobiological impact of concussion is crucial for recovery and return-to-play decisions.
  • Multimodal neuroimaging offers a comprehensive approach to assess brain function and structure.

Purpose of the Study:

  • To compare neurophysiological and neuroimaging findings between dizygotic twin sisters with and without a recent concussion.
  • To investigate the acute and subacute effects of a first-time concussion using a multimodal approach.
  • To assess the potential of advanced imaging techniques in localizing concussion effects and informing clinical management.

Main Methods:

  • Utilized magnetoencephalography (MEG), electroencephalography (EEG), diffusion kurtosis imaging (DKI), pseudo-continuous arterial spin labelling (pCASL), and resting-state functional MRI (rs-fMRI).
  • Compared a concussed twin (Twin A) with her non-concussed twin sister (Twin B) across three timepoints (T1: 72 hours post-concussion, T2: 1 month, T3: 3 months).
  • Acquired data using harmonized protocols on a 3T Siemens Prisma scanner and a MEGIN Triux Neo system.

Main Results:

  • The concussed twin (Twin A) exhibited acute symptoms, left frontal hypoperfusion, reduced rs-fMRI power, and increased low-frequency electrophysiological activity at T1.
  • Twin A demonstrated gradual recovery across all assessed modalities over the 3-month period.
  • The non-concussed twin (Twin B) showed stable findings across all assessments, serving as an effective control.

Conclusions:

  • Multimodal brain imaging can effectively detect and localize the neurobiological changes associated with sports-related concussion.
  • These advanced imaging techniques show promise in objectively informing return-to-play decisions for athletes.
  • The study underscores the utility of comparing affected and unaffected twins for understanding concussion pathophysiology.