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Related Experiment Video

Updated: Feb 28, 2026

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Integrated transcriptomic characterization and ceRNA network analysis during early liver development in goat kids.

Qing Li1,2, Qingling Duan1,2, Jianmin Wang1,2

  • 1Shandong Provincial Key laboratory for Livestock Germplasm Innovation & Utilization, College of Animal Science and Technology, Shandong Agricultural University, Tai'an City, Shandong Province 271014, China.

Journal of Animal Science
|February 25, 2026
PubMed
Summary

This study reveals how liver metabolism changes in young goats after weaning, identifying key genes and regulatory networks involved in growth and immune adaptation. These findings offer insights into ruminant liver development.

Keywords:
ceRNA networkgoat kidslipid metabolismlivertranscriptome

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Area of Science:

  • Molecular Biology
  • Genomics
  • Ruminant Physiology

Background:

  • The transition from milk to solid feed triggers significant metabolic changes in mammalian livers.
  • Understanding the transcriptional regulation of liver adaptation post-birth is crucial for animal development.

Purpose of the Study:

  • To investigate the dynamic transcriptomic profiles and competing endogenous RNA (ceRNA) regulatory networks in goat livers from birth to post-weaning.
  • To elucidate the molecular mechanisms of hepatic metabolic reprogramming and immune adaptation during early development in ruminants.

Main Methods:

  • Dynamic transcriptomic profiling of goat liver tissues at multiple time points (birth to 12 weeks).
  • Weighted gene co-expression network analysis (WGCNA) to identify key gene modules and pathways.
  • Construction and validation of a lipid metabolism-associated ceRNA network.

Main Results:

  • Key genes involved in PPAR signaling and fatty acid biosynthesis (e.g., PPARG, FASN) showed high expression during suckling, indicating active hepatic lipogenesis.
  • Differentially expressed long non-coding RNAs (DELs) were identified, with targets enriched in immune pathways (e.g., NF-κB, Th17 cell differentiation), suggesting roles in immune transition and weaning stress response.
  • A lipid metabolism-associated ceRNA network was constructed, including validated axes like miR-497-5p-FASN-MSTRG.9465.3.

Conclusions:

  • The study provides novel insights into the transcriptional regulatory mechanisms governing early liver development and metabolic adaptation in ruminants.
  • The identified ceRNA networks highlight the complex interplay between lipid metabolism and immune system development during the critical post-weaning transition.
  • Findings contribute to a better understanding of hepatic adaptation and stress response in young ruminants.