Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

1.5K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ACPGBI position statement on the role of standard high-quality right hemicolectomy and complete mesocolic excision in right-sided colon cancer.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

A standardised approach to the pathological dissection and reporting of pelvic exenteration specimens: Recommendations from the UK Pelvic Exenteration Network (UKPEN).

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

Corrigendum to "Neo-adjuvant FOLFOX with and without panitumumab for patients with KRAS-wt locally advanced colon cancer: results following an extended biomarker panel on the FOxTROT trial embedded phase II population": [Ann Oncol 36 (2025) 520-528].

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Defining Standard Data Reporting in Pelvic Exenterations for Non-Rectal Cancers: A Systematic Review of Current Data Reporting.

Cancers·2025
Same author

Is computed tomography assessment of residual arterial pedicle length following colorectal cancer surgery a useful marker of surgical quality?

Techniques in coloproctology·2025
Same author

Neo-adjuvant FOLFOX with and without panitumumab for patients with KRAS-wt locally advanced colon cancer: results following an extended biomarker panel on the FOxTROT trial embedded phase II population.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Related Experiment Video

Updated: Feb 28, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

4.5K

Reconsidering the 1 mm rule: Contextualising R1 margin status in rectal cancer.

J D Mason1, K Naidu2, J Tiernan2

  • 1Department of Colorectal Surgery, Oxford University Hospitals, Churchill Hospital, Oxford, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|February 25, 2026
PubMed
Summary

The 1 mm rule for rectal cancer resection margins needs context-specific interpretation. Evidence suggests tailored R1 definitions for locally advanced, recurrent, and early rectal cancers improve oncological accuracy.

Keywords:
locally advanced rectal cancerlocally excised rectal cancerlocally recurrent rectal cancerresection margin

More Related Videos

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.8K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

1.9K

Related Experiment Videos

Last Updated: Feb 28, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
04:45

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

4.5K
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.8K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

1.9K

Area of Science:

  • Oncology
  • Surgical Pathology
  • Cancer Research

Background:

  • The 1 mm rule for circumferential resection margin (CRM) involvement is standard for rectal cancer, defining R1 resection. Its universal application is questioned due to advances in imaging, surgery, and pathology.
  • Context-specific interpretation of R1 status is needed for encapsulated nodal involvement in locally advanced rectal cancer (LARC), locally recurrent rectal cancer (LRRC), and locally excised early rectal cancer (LERC).

Purpose of the Study:

  • To challenge the uniform application of the 1 mm rule for CRM in rectal cancer.
  • To explore the biological and clinical relevance of close margins in LARC, LRRC, and LERC.

Main Methods:

  • Review of current literature, international datasets, and emerging evidence.
  • Analysis of The International Collaboration on Cancer Reporting (ICCR) dataset, Royal College of Pathologists (RCPath) guidance, and large cohort/registry data.

Main Results:

  • The prognostic value of the 1 mm rule varies by anatomical and pathological context.
  • In LARC, lymph node metastasis abutting CRM without extracapsular extension is biologically R0.
  • For LRRC, margins >0 mm show equivalent outcomes to wider margins, supporting a 0 mm R1 definition. In LERC, ≤1 mm margins may be acceptable without high-risk features.

Conclusions:

  • A tailored approach to R1 definition is supported by current evidence.
  • Aligning R1 classification with modern oncological, anatomical, and pathological realities enhances accuracy.