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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch

Julie Eichler1,2,3,4, Corinne Wendling1,2,3,4, Sophie Huver1,2,3,4

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.

The EMBO Journal
|February 25, 2026
PubMed
Summary

Glycogen synthase kinase 3 (GSK3) phosphorylates STARD3, activating its role in forming membrane contact sites (MCS) between late endosomes/lysosomes and the endoplasmic reticulum. This phosphorylation is crucial for organelle communication and endosome function.

Keywords:
Endoplasmic ReticulumEndosomeLipid Transfer ProteinMembrane Contact SitePhosphorylation

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