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Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies
Spandana Rajendra Kopalli1, Mayur B Kale2, Akanksha Yadav2
1Department of Bioscience and Biotechnology, Sejong University, Gwangjin-Gu, Seoul, 05006, Republic of Korea.
Biogerontology
|February 25, 2026
Summary
Neuroplasticity, the brain
Area of Science:
- Neuroscience
- Aging Research
- Cognitive Science
Background:
- Cognitive aging is characterized by declines in memory, processing speed, and executive functions.
- These declines are linked to reduced neuroplasticity, including synaptic plasticity and neurogenesis.
- Factors like oxidative stress and neuroinflammation accelerate age-related cognitive deterioration.
Purpose of the Study:
- To review the role of neuroplasticity in cognitive aging.
- To discuss interventions promoting neuroplasticity for cognitive health.
- To highlight challenges and future directions in personalized interventions.
Main Methods:
- Literature review on neuroplasticity mechanisms in aging.
- Analysis of factors influencing neuroplasticity.
- Examination of current and potential interventions.
Main Results:
- Synaptic plasticity supports learning, but adult neurogenesis in humans is limited.
- Functional reorganization aids cognitive function despite age-related changes.
- Interventions like cognitive training and exercise show promise but require personalization.
Conclusions:
- Personalized strategies are crucial for enhancing neuroplasticity in the aging brain.
- Future research should focus on modulating specific neuroplasticity processes.
- Targeted interventions may delay or reverse age-related cognitive decline.
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