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Improving Translational Accuracy

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

Improving Translational Accuracy

Improving Translational Accuracy

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: Feb 28, 2026

Author Spotlight: Enhancing CAR-T Cell Function in Syngeneic Tumor Models

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Published on: February 2, 2024

Enhancing CAR-T cell activity prediction via fine-tuning protein language models with generated CAR sequences

Kei Yoshida¹, Shoji Hisada², Ryoichi Takase³

¹Next Research, Research and Development Group, Hitachi, Ltd., Hyogo, Japan. kei.yoshida.qp@hitachi.com.

BMC Bioinformatics

|February 25, 2026

Summary

No abstract available in PubMed .

Keywords:

CAR-T cell Data augmentation Fine-tuning Protein language models Sequence-based prediction

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