Effects of hypertonic glucose and amino acid infusions on pancreatic exocrine function

Inhibiting effects of hypertonic glucose and amino-acids on pancreatic exocrine function were studied using mongrel dogs with chronic gastric and pancreatic fistulae. Under the basal stimulation with secretin and pancreoxymin, 20% glucose, 30% glucose and 12% amino acids were given intravenously. Infusion of these substances caused the maximal decreases in pancreatic juice volume and amylase output, to 23% and 11%, respectively (20% glucose), 32% and 29% (30% glucose), and 53% and 42% (12% amino acids). But no significant changes were noted in bicarbonate concentration. When glucose was infused, the rise in levels of blood sugar and IRI was associated with the inhibition of pancreatic exocrine secretion. Aminoacid infusion produced the greatest inhibitory effect on the pancreatic secretion and markedly elevated both the levels of IRI and IRG. Intravenous infusion of glucagon suppressed notably the exocrine function of the pancreas.