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DPSC-EVs Drive Functional Recovery in Sjögren's Disease by Systemic Immunomodulation

Tatsuya Kawado1, Kenichi Ogata1,2, Masafumi Moriyama3

  • 1Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

Tissue Engineering. Part A
|February 26, 2026
PubMed
Summary

Dental pulp stem cell extracellular vesicles (DPSC-EVs) show promise for Sjögren's disease (SjD). A single DPSC-EV dose improved salivary function and reduced inflammation by modulating immune cells in the spleen.

Keywords:
Sjögren’s diseaseTGF-β/Smad signalingdental pulp stem cellsextracellular vesicles

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