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Updated: Feb 28, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Recent advancements in carbonylative synthesis of quinolinones
Mariangela Novello1,2, Raffaella Mancuso1, Bartolo Gabriele1
1Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy. raffaella.mancuso@unical.it.
Abstract:
Carbonylation reactions, which rely on the controlled incorporation of carbon monoxide into organic substrates, represent a key tool in both organic and industrial chemistry. Carbonylation offers an efficient route to carbonyl-containing compounds starting from simple and readily available substrates, and it remains a highly active area of research in organometallic chemistry and catalysis. Current efforts focus on developing new catalysts, more efficient and sustainable methodologies, and innovative applications in emerging areas such as green chemistry and asymmetric synthesis. Given the great importance of heterocyclic compounds, the carbonylative approach has become increasingly important for their synthesis. In this review, we summarize and discuss advancements in the synthesis of quinolinone derivatives, a class of benzo-fused nitrogen-containing heterocyclic compounds, via carbonylative approaches.
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