Related Experiment Video
Updated: Feb 28, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Vitamin D Pretreatment to Prevent the Risk of Postoperative Hypocalcemic Complications After Parathyroidectomy in
Matthew Gynn1, Helia Mansouri Dana2, Oleksandr Butskiy1
1Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Background:
Parathyroidectomy is the treatment for primary hyperparathyroidism, yet postoperative hypocalcemia and hungry bone syndrome remain common. Vitamin D deficiency has been suggested as a modifiable risk factor, but evidence supporting preoperative supplementation is inconsistent.
Methods:
Following PRISMA guidelines, we systematically searched five databases (up to January 2025) for studies evaluating vitamin D supplementation before parathyroidectomy in primary hyperparathyroidism. Data were extracted in duplicate, risk of bias assessed, and random-effects meta-analyses performed.
Results:
Nine studies (three RCTs and six cohorts; n = 2750) were included. Vitamin D supplementation significantly reduced postoperative hypocalcemia (RR: 0.35, 95% CI: 0.18-0.66), symptomatic hypocalcemia (RR: 0.53, 95% CI: 0.29-1.00), and length of stay (MD: -0.51 days, 95% CI: -0.55 to -0.46). Trends favored supplementation for decreasing the risk of hungry bone syndrome and requiring calcium supplementation.
Conclusions:
Preoperative vitamin D appears safe and may reduce hypocalcemia-related complications after parathyroidectomy, though current evidence is of low quality.
More Related Videos
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Related Concept Videos
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:21Skeleton and Calcium Homeostasis
00:51Synthesis and Functions of Calcitonin
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
01:23Peripheral Artery Disease V: Postoperative Nursing Management
01:23Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...