Related Experiment Videos
Severe Necrotizing Locally Advanced Basal Cell Carcinoma With Osteomyelitis.
Anjie Ge1, Jacob P Reinhart2, Michael J Camilleri2,3
1Mayo Clinic Alix School of Medicine, Rochester, MN, USA.
Advances in Skin & Wound Care
|February 26, 2026
Summary
Locally advanced basal cell carcinoma (BCC), a rare skin cancer, can manifest as chronic ulcers. This case report details a successful multidisciplinary treatment approach for a patient with extensive BCC.
Area of Science:
- Dermatology
- Oncology
Background:
- Locally advanced basal cell carcinoma (BCC) is an uncommon and complex presentation of basal cell carcinoma.
- These tumors can present as extensive nonhealing ulcers, necessitating biopsy to exclude other conditions like infections or inflammatory diseases.
Purpose of the Study:
- To report a case of locally advanced basal cell carcinoma presenting as a chronic ulcer.
- To highlight the diagnostic process and multidisciplinary management of this rare condition.
Main Methods:
- A case report of a 57-year-old female with a 5-year history of a progressive ulcer on the neck and back.
- Histopathological examination confirmed nodular and infiltrative basal cell carcinoma.
- Treatment involved a multidisciplinary approach including vismodegib, radiation, and surgery.
Main Results:
- Histopathology confirmed nodular and infiltrative basal cell carcinoma.
- The patient underwent a multidisciplinary treatment regimen.
- The case highlights the complexity of diagnosing and managing extensive BCC.
Conclusions:
- Locally advanced basal cell carcinoma requires thorough investigation, including biopsy, to differentiate from other etiologies.
- Multidisciplinary management involving targeted therapy, radiation, and surgery is crucial for effective treatment of extensive BCC.
