BLOSSOM Dietary Habits and 1-Year Intravesical Recurrence in High-Risk Non-Muscle-Invasive Bladder Cancer Treated...

Area of Science:

• Oncology
• Nutrition Science
• Urology

Background:

• Limited evidence exists on modifiable factors impacting outcomes after intravesical Bacillus Calmette-Guérin (BCG) therapy for high-risk non-muscle-invasive bladder cancer (NMIBC).
• Understanding dietary influences could optimize treatment efficacy and patient prognosis.

Purpose of the Study:

• To investigate associations between dietary factors and intravesical recurrence in BCG-naïve NMIBC patients.
• To assess the feasibility of collecting dietary data in this patient population.

Main Methods:

• Prospective, multicenter cohort study involving 46 BCG-naïve NMIBC patients.
• Repeated 24-hour dietary recalls were administered.
• Firth's penalized logistic regression was used to analyze associations between food groups, nutrients, and 1-year intravesical recurrence, with FDR control.

Main Results:

• Eight recurrences (19.5%) were observed among 41 evaluable patients.
• No dietary exposures met the false discovery rate threshold for significance.
• Nominal inverse associations were noted for leafy green vegetables, zinc, and magnesium, but these did not persist after adjustment.

Conclusions:

• This exploratory study found no statistically significant dietary factors associated with bladder cancer recurrence after BCG therapy.
• The observed nominal associations warrant further investigation in larger cohorts with dietary biomarkers.
• Findings are hypothesis-generating due to small sample size and low event count.