Search research articles

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of an Antibacterial Coating Based on PVP-PEG Fibers Incorporating Silver Nanoparticles and a Method for Its Application to Skin.

Polymers·2026

Same author

Capacity of Arctic fjord sediments to degrade carbohydrates from permafrost active layer.

Microbiology spectrum·2026

Same author

CO<sub>2</sub>-Induced Foaming and Gelation for the Fabrication of Macroporous Alginate Aerogel Scaffolds.

Gels (Basel, Switzerland)·2026

Same author

Polyacrylonitrile Nanofiber Mats Produced by Solution Blow Spinning: Influence of Process Parameters on Fiber Diameter and Residual Solvent Content.

Polymers·2026

Same author

Investigation of Rheological Characteristics of Thermosensitive Nasal In Situ Gels Based on P407 and Their Effect on Spray Pattern.

Gels (Basel, Switzerland)·2025

Same author

Characterizing Microbial Communities in >7000- and >180,000-Year-Old Antarctic Permafrost Using a Low-Biomass Decontamination Protocol.

Astrobiology·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Multi-Material Extrusion-Based 3D Printing of Hybrid Scaffolds for Tissue Engineering Application.

Andrey Abramov¹, Yan Sulkhanov¹, Natalia Menshutina¹

¹Department of Chemical and Pharmaceutical Engineering, Mendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, 125047 Moscow, Russia.

Gels (Basel, Switzerland)

|February 26, 2026

Summary

This study presents a novel 3D printing platform for creating hybrid scaffolds using hydrogels and thermoplastics. The system ensures precise material deposition for advanced tissue engineering applications.

Keywords:

direct ink writing (DIW)extrusion-based 3D printing hydrogel inks hydrogel–thermoplastic hybrid scaffolds multi-material 3D printing printability and dosing accuracy process parameters tissue engineering

More Related Videos

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Related Experiment Videos

Last Updated: Feb 27, 2026

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

Area of Science:

Biomaterials Engineering
Additive Manufacturing
Tissue Engineering

Background:

Additive manufacturing of hydrogel scaffolds demands precise control over material properties and extrusion.
Multi-material architectures present unique challenges in controlling rheology and deposition dynamics.

Purpose of the Study:

To develop a modular, multi-material 3D printing platform for fabricating hybrid hydrogel-thermoplastic scaffolds.
To implement an empirical calibration procedure for accurate gel dosing in extrusion-based printing.

Main Methods:

A modular platform combining filament and piston-driven extruders was developed.
An empirical calibration algorithm optimized extrusion parameters (EPr/R) for shear-thinning alginate gels.
Two hybrid constructs were fabricated: alginate scaffolds with polycaprolactone framework and alginate-chitosan complex structures.

Main Results:

The calibration algorithm reduced deposition mass discrepancy to below tolerance.
Fabricated constructs demonstrated mechanical stability after crosslinking and solvent treatment.
The 3D-printed scaffolds were successfully converted into highly porous structures via freeze- or supercritical drying.

Conclusions:

The developed system enables reproducible multi-material 3D printing of hydrogel-thermoplastic hybrid scaffolds.
The hardware and calibration approach are adaptable to various gel-based inks for tissue engineering.
This technology facilitates the creation of complex scaffolds for regenerative medicine.