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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Left Atrioventricular Coupling Index Predicts Poor Prognosis in Acute Myocardial Infarction: A Single-Center Cohort

Chuyun Chen1, Haolei Huang1, Jia Jia1,2

  • 1Department of Cardiology, Peking University First Hospital, Beijing 100034, China.

Journal of Cardiovascular Development and Disease
|February 26, 2026
PubMed

Insights

The novel left atrioventricular coupling index (LACI) predicts poor outcomes in acute myocardial infarction (AMI) patients. Higher LACI levels are linked to increased risks of major adverse cardiovascular events (MACE), aiding in secondary prevention strategies.

Area of Science:

  • Cardiology
  • Echocardiography
  • Clinical Research

Background:

  • The left atrioventricular coupling index (LACI) is a new parameter for assessing cardiac function.
  • Its association with major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients requires further investigation.

Purpose of the Study:

  • To evaluate the association between LACI and MACE in patients with AMI.
  • To determine LACI's utility in risk stratification for secondary prevention.

Main Methods:

  • Retrospective cohort study of 843 AMI patients.
  • Transthoracic echocardiography performed on admission for LACI measurement.
  • Median follow-up of 4.31 years with MACE as the primary endpoint.

Main Results:

  • Median LACI was 0.24; 17.91% of patients experienced MACE.
  • Optimal LACI cutoff for risk stratification identified as 0.257.
  • Increased LACI associated with higher risks of MACE, all-cause death, cardiovascular death, and stroke after multivariable adjustment.

Conclusions:

  • LACI is an independent predictor of poor prognosis in AMI patients.
  • LACI can be a valuable tool for risk stratification in secondary prevention strategies.

Keywords:
cohort studyechocardiographyleft atrioventricular coupling indexmajor adverse cardiovascular events

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