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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Feb 27, 2026

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

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Bone Tissue Engineering: Recent Advances and Translation to Clinical Application.

Fernando P S Guastaldi^1,2, Bhushan Mahadik³

¹Division of Oral and Maxillofacial Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

Journal of Functional Biomaterials

|February 26, 2026

Summary

Addressing large bone defects is crucial in reconstructive surgery. Innovative strategies are needed to regenerate bone tissue and restore function after significant bone loss.

Area of Science:

Orthopedic Surgery
Regenerative Medicine
Biomaterials Science

Background:

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Large bone defects pose significant challenges in orthopedic, maxillofacial, and reconstructive surgery.

Defects arise from trauma, tumor resection, congenital anomalies, infection, or revision procedures.

Current treatments often have limitations in fully restoring bone structure and function.