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Cardiovascular Functioning Features in Individuals with Connective Tissue Dysplasia Engaged in Sports for the
Kamiliia Vinokurova1, Anna Zakharova1, Yulia Zinovieva2
1Institute of Physical Education, Sports and Youth Policy, Ural Federal University, Ekaterinburg 620002, Russia.
Sports (Basel, Switzerland)
|February 26, 2026
Summary
Athletes with connective tissue dysplasia and left ventricular false tendons show that sport type impacts heart function more than disability type. Individual screening of VO2max and QTc is crucial for training load prescription.
Area of Science:
- Cardiology
- Sports Medicine
- Genetics
Background:
- Connective tissue dysplasia (CTD) affects collagen synthesis and is prevalent in diverse populations.
- Left ventricular false tendons (LVFTs) are common cardiac manifestations of CTD, influencing left ventricular function.
- Understanding the cardiac response to exercise in athletes with disabilities and CTD is essential for performance optimization and safety.
Purpose of the Study:
- To investigate the impact of sports specialization and disability type on the cardiac functional reserve of athletes with CTD and LVFTs.
- To identify key cardiovascular indicators that differentiate responses to physical activity in this population.
Main Methods:
- A cohort of 610 individuals with disabilities and LVFTs (aged 6-60) participated, representing 10 sports disciplines and 4 disability types.
- Cardiovascular assessments included transthoracic echocardiography (TTE), impedance cardiography, and ECG (resting and stress tests).
- Statistical analyses (ANOVA, Kruskal-Wallis) were employed to compare 141 cardiorespiratory and exercise parameters across sports and disability categories.
Main Results:
- Maximum oxygen consumption (VO2max) and corrected QT interval (QTc) were the primary indicators showing statistically significant differences based on sports specialization and disability.
- The type of athletic activity demonstrated a more pronounced effect on VO2max and QTc compared to the type of disability.
- Specific P-values indicated significant variations in VO2max (0.00063 for disciplines, 0.01028 for categories) and QTc (0.00001 for disciplines, 0.02185 for categories).
Conclusions:
- Sport specialization plays a more significant role in engaging the heart's functional reserve among athletes with disabilities and CTD than the type of disability.
- Individualized cardiology screening, focusing on VO2max and QTc, is recommended for prescribing training loads in this population.
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