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Updated: Feb 27, 2026

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Base-Promoted S-Alkylation of Sulfenamides with Cyclic Sulfonium Salts
Ye Liu1, Mengqi Zhang1, Zian Zhang1
1School of Medical Engineering, Jining Medical University, Jining 272067, P. R. China.
Abstract:
S-alkylation of sulfenamides is a promising strategy to access sulfilimine compounds that play important roles in chemical biology and synthetic chemistry. Herein, we report a base-promoted S-alkylation of sulfenamides with cyclic sulfonium salts as alkylating reagents, which delivered the sulfilimines featuring alkenyl/alkynyl thioether moieties. This practical method shows the advantages of mild conditions, operational simplicity, and broad substrate scope. Moreover, the synthetic potential of this method was demonstrated by a one-pot synthesis and late-stage diversification of drug-relevant molecules.
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