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Related Experiment Video

Updated: Feb 27, 2026

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CanRestoreFunction: Cancer-related fatigue management eHealth intervention- a pilot pragmatic randomized-control

Anne B Fleischer1, Mary Insana Fisher2, Wei-Wen Hsu3

  • 1Department of Rehabilitation, Exercise and Nutrition Sciences, University of Cincinnati, 3225 Eden Ave., Cincinnati, Ohio, 45267, USA. Anne.Fleischer@uc.edu.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|February 26, 2026
PubMed
Summary
This summary is machine-generated.

An 8-week eHealth intervention significantly reduced cancer-related fatigue and improved quality of life in women with breast cancer. This multi-modal approach, including remote education and exercise, showed clinically meaningful results.

Keywords:
Cancer-related fatigueOccupational therapyPhysical therapyQuality of lifeRehabilitationeHealth

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Area of Science:

  • Oncology
  • Digital Health
  • Patient Support

Background:

  • Cancer-related fatigue (CRF) significantly impacts the quality of life for breast cancer survivors.
  • Existing interventions for CRF may have limitations in accessibility and adherence.

Purpose of the Study:

  • To evaluate the effectiveness of an 8-week multi-modal eHealth intervention for reducing cancer-related fatigue (CRF) in women with breast cancer.
  • To assess the intervention's impact on quality of life and explore recruitment and retention strategies.

Main Methods:

  • A randomized controlled trial involving women (18-70 years) with Stage 0-3 breast cancer and significant fatigue.
  • Participants were assigned to an eHealth intervention (remote education, exercise, problem-solving) or a control group.
  • Cancer-related fatigue and quality of life were measured pre- and post-intervention using validated scales.

Main Results:

  • Social media facilitated participant recruitment, though the eHealth group experienced higher dropout rates.
  • Both groups showed significant reductions in fatigue over time (p=0.001).
  • The eHealth intervention achieved a minimally clinically important difference in fatigue reduction and significantly improved quality of life compared to the control (p=0.03).

Conclusions:

  • A multi-modal eHealth intervention can effectively reduce cancer-related fatigue and enhance quality of life in breast cancer survivors.
  • The findings support the integration of digital health solutions into survivorship care.
  • Further research may explore strategies to optimize retention in eHealth interventions.