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Updated: May 11, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
A well-known marker for predicting peritoneal metastasis in gastric cancer: carbohydrate antigen 125
Hikmet Pehlevan-Özel1, Eda Şahingöz2, Tolga Dinç3
1Department of Surgery, Mamak State Hospital.
Objectives:
Detection of peritoneal metastasis in gastric cancer is still not successful enough despite all the tests performed. In this study, the success of five well-known and commonly used tumor markers in detecting peritoneal metastasis was investigated.
Method:
A total of 361 patients with 61 peritoneal metastases and 25 distant organ metastasis were included in the study. The relationship between tumor markers and peritoneal metastases was investigated.
Results:
There was a statistically significant correlation between carbohydrate antigen (CA) 125 and the presence of peritoneal metastasis in gastric cancer (p < 0.001). CA 125 values > 22.75 U/mL were significantly associated with peritoneal metastasis (Area under the curve: 0.771, Sensitivity: 73.5%, Specificity: 77.7%, 95% confidence interval: 0.667-0.875). No correlation was found between the presence of peritoneal metastasis and carcinoembryonic antigen, CA 19-9, CA 15-3, and α-fetoprotein levels (p = 0.197, p = 0.087, p = 0.497, p = 0.128, respectively).
Conclusion:
CA 125 is an effective, non-invasive, easily accessible marker for predicting peritoneal metastasis. At levels > 22.75 U/mL, the risk of peritoneal metastasis in gastric cancer can be predicted.
