Understanding the Role of Gut Microbial Enzyme in CMD

Area of Science:

• Microbiology
• Metabolic diseases
• Enzymology

Background:

• Cardiometabolic diseases (CMDs) are a leading cause of global mortality.
• Gut microbiota's role in CMD pathogenesis is increasingly understood mechanistically.
• Microbial enzymes are critical regulators of host-microbe interactions and metabolism.

Purpose of the Study:

• To review microbial enzymes involved in cardiometabolic disease (CMD) development.
• To elucidate mechanisms by which microbial enzymes influence CMD.
• To explore strategies for microbial enzyme-based CMD interventions.

Main Methods:

• Systematic review of literature on microbial enzymes and CMD.
• Analysis of enzyme roles in host metabolite and xenobiotic metabolism.
• Discussion of enzyme mining and intervention strategies.

Main Results:

• Microbial enzymes modulate host metabolite homeostasis (e.g., cholesterol).
• These enzymes generate bioactive molecules impacting host immunity and metabolism.
• Microbial enzymes are involved in drug metabolism and xenobiotic transformation.

Conclusions:

• Microbial enzymes are key targets for precision interventions in CMD.
• Strategies include enzyme replacement, agonists/inhibitors, and gene editing.
• Targeting microbial enzymes holds promise for specific and controllable CMD treatment.