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Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

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RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Related Experiment Video

Updated: Feb 28, 2026

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
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Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

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STING takes on RNA viruses.

Nan Yan1

  • 1Departments of Immunology and Microbiology, University of Texas at Southwestern Medical Center, Dallas, TX, USA.

Science (New York, N.Y.)
|February 26, 2026
PubMed
Summary

A newly discovered signaling pathway effectively inhibits DNA virus replication. This pathway also provides protection against RNA viruses, broadening its antiviral potential.

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Viral replication mechanisms are diverse for DNA and RNA viruses.
  • Understanding conserved antiviral pathways is crucial for broad-spectrum therapeutics.

Purpose of the Study:

  • To investigate a specific signaling pathway's role in viral replication.
  • To determine if this pathway impacts both DNA and RNA viruses.

Main Methods:

  • Utilized molecular biology techniques to study the signaling pathway.
  • Performed viral replication assays for DNA and RNA viruses in the presence of pathway modulators.

Main Results:

  • The signaling pathway significantly inhibited DNA virus replication.

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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

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Related Experiment Videos

Last Updated: Feb 28, 2026

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
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High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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  • The same pathway demonstrated protective effects against RNA virus infection.

    • Conclusions:

    • A conserved signaling pathway offers broad antiviral defense.
    • This pathway represents a potential target for novel antiviral strategies.