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Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in

Xiaoyan Shao1,2, Pan Zhang1,3,4,5, Zhidan Fan2

  • 1Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 26, 2026
PubMed
Summary

Extracellular vesicles (EVs) from aging muscle inhibit bone formation. Blocking muscle EV production or targeting miR-125a-5p can reverse bone loss, offering new osteoporosis therapies.

Keywords:
MiR‐125a‐5pbone formationextracellular vesiclesmuscle atrophyosteoporosis

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