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Patients With Urinary Urgency Have Central Sensitization Symptoms-A LURN II Phenotyping Study
H Henry Lai1, Alan J Fossa2, Brian Bieber2
1Department of Urology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
The Journal of Urology
|February 26, 2026
Summary
Patients with urinary urgency, including overactive bladder (OAB), show higher central sensitization symptoms. This suggests central sensitization may contribute to urinary urgency and incontinence in a subset of patients.
Area of Science:
- Urology
- Neuroscience
- Pain Medicine
Background:
- Urinary urgency and overactive bladder (OAB) significantly impact quality of life.
- Central sensitization, a condition involving amplified pain signaling, is increasingly recognized in various chronic conditions.
Purpose of the Study:
- To investigate the prevalence and impact of central sensitization in patients experiencing urinary urgency, with or without urgency urinary incontinence (UUI).
Main Methods:
- Adult patients with urinary urgency (with or without UUI) seeking OAB treatment and healthy controls were enrolled in the LURN II Study.
- The Central Sensitization Inventory (CSI) questionnaire was used to assess symptoms of central sensitization, with CSI scores of 40 or higher indicating a higher likelihood of the condition.
Main Results:
- Patients with urinary urgency had significantly higher CSI scores compared to controls (median 28.0 vs. 15.0).
- 21% of patients with urinary urgency were likely to have central sensitization (CSI≥40), compared to only 3.2% of controls (p<0.001).
- Higher CSI scores correlated with increased OAB symptom severity, urgency and incontinence symptoms, and reduced quality of life.
Conclusions:
- Patients with OAB and urinary urgency exhibit more central sensitization symptoms than controls.
- Central sensitization appears to be a contributing factor in at least a subset of individuals with urinary urgency, potentially impacting UUI.
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