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The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Feb 28, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

Spatial Transcriptomic Analysis Reveals Dysregulated Pro-Inflammatory Signaling in the Aged Lung.

Brianna M Doratt¹, Ethan G Napier¹, Mahdi Eskandarian Boroujeni¹

¹Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA.

Aging and Disease

|February 26, 2026

Summary

This summary is machine-generated.

Aged lungs show a pro-inflammatory bias, increasing susceptibility to respiratory infections. This study used spatial transcriptomics in rhesus macaques to reveal immune and cellular differences between young and old lungs.

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Published on: March 21, 2021

Area of Science:

Immunology
Aging Research
Respiratory Medicine

Background:

Older individuals face higher risks of respiratory infections due to lung changes and inflammation.
Mechanisms underlying age-related respiratory vulnerability are not fully understood.
Rodent models have limitations in translating findings to human respiratory diseases.

Purpose of the Study:

To investigate age-related differences in lung transcriptional landscapes.
To identify cellular and molecular mechanisms contributing to increased respiratory infection susceptibility in older individuals.
To utilize rhesus macaques as a translational model for human lung aging.

Main Methods:

Visium spatial transcriptomics was employed to analyze lung tissue from young and aged rhesus macaques.
Gene expression patterns were compared between age groups to identify differential cellular responses.
Immune and structural cell clusters were identified and characterized.

Main Results:

Aged lungs exhibited a pro-inflammatory transcriptional bias compared to a regulatory phenotype in young lungs.
Key cellular signaling pathways for adhesion and tissue maintenance were reduced in aged lungs.
Significant differences in immune cell populations and gene expression were observed between young and aged macaques.

Conclusions:

Aged lungs are predisposed to hyperinflammatory responses, potentially leading to increased immune-mediated damage.
These findings highlight age-related immune dysregulation in the lung.
Rhesus macaques offer a valuable model for studying human lung aging and disease.