Related Experiment Video
Updated: Jul 17, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Comparative Evaluation of AmnioGuard and Advanced Platelet-Rich Fibrin When Combined With NovaBone Putty in the
Geeta Bhandari1, Priyanka Jaiswal1, Shweta Bhagat1
1Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research (DMIHER(DU)), Sawangi, Wardha, 442001, India, 91 8237719188.
Background:
Periodontitis causes progressive attachment loss, which in turn causes tooth mobility and, ultimately, tooth loss. Regenerating and rebuilding the lost periodontal tissue is the goal of periodontal regenerative surgery. Regeneration using AmnioGuard, advanced platelet-rich fibrin (A-PRF), and NovaBone Putty has been demonstrated to be successful in increasing clinical attachment level and decreasing probing pocket depth.
Objective:
This study aims to compare and evaluate the effectiveness of AmnioGuard and A-PRF membrane in combination with NovaBone Putty in the regeneration of human periodontal infrabony defects.
Methods:
A total of 24 patients will be selected and divided into 2 groups: group A (n=12, 50%) and group B (n=12, 50%). Group A will receive treatment with NovaBone Putty and AmnioGuard, whereas group B will receive treatment with autologous A-PRF and NovaBone Putty. Plaque index, clinical attachment level, probing pocket depth, complete mouth bleeding score, and intraoral periapical radiographs will be statistically analyzed. Clinical and radiographic features will be evaluated before surgery and 6 months following the procedure.
Results:
Recruitment began on September 16, 2025, and is ongoing. As of manuscript submission, 4 participants have been enrolled. Results are expected to be published in 2027. All the clinical measurements will be recorded after 6 months. It can be anticipated that AmnioGuard membrane with NovaBone Putty will provide additional benefits in the management of chronic periodontitis by promoting better healing and clinical outcomes.
Conclusions:
Within the constraints of this study, the AmnioGuard membrane combined with NovaBone Putty may be more effective in the treatment of chronic periodontitis.
Related Concept Videos
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...