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Updated: Feb 28, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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Discovery of a potent thienodiazepine derivative as a novel BRD4 degrader

Mayu Shigekuni1, Yasuki Niwa1, Kiyomi Ohba1

  • 1Research Division, Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.

Bioorganic & Medicinal Chemistry
|February 26, 2026
PubMed

Keywords:
Acute myeloid leukemia (AML)BRD4Structure activity relationship (SAR)Targeted protein degradationThienodiazepineVHL

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