Related Experiment Video
Updated: Feb 28, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Recommendations from the 2nd Consensus Workshop on Analytical Treatment Interruption in HIV Research Trials
Thumbi Ndung'u1, Krista L Dong2, Donn J Colby3
1Africa Health Research Institute, Durban, South Africa; Division of Infection and Immunity, University College London, London, UK; Ragon Institute of Mass General Brigham, MIT, and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Updated guidelines for analytical treatment interruption (ATI) studies in HIV research now feature more flexible entry criteria and allow longer viral load blips to assess immune control. These revisions aim to advance the search for an HIV cure safely and ethically.
Area of Science:
- Immunology
- Virology
- Clinical Trials
Background:
- Analytical treatment interruption (ATI) is crucial for evaluating HIV eradication strategies.
- Previous ATI study guidelines required updates based on evolving research and community input.
Purpose of the Study:
- To update and revise the recommendations for conducting analytical treatment interruption (ATI) studies.
- To ensure the safe and ethical implementation of next-generation ATI trials for HIV cure research.
Main Methods:
- Convened a stakeholder workshop to discuss and revise existing ATI study protocols.
- Incorporated expert opinion, current data, and community consultation into updated recommendations.
Main Results:
- Revised entry criteria for ATI studies, including CD4 count, nadir, and medical history.
- Modified criteria for antiretroviral therapy resumption, allowing longer/higher viral load periods to gauge immune response.
- Included specific recommendations for pediatric and adolescent ATI trials.
- Emphasized psychosocial support, HIV transmission prevention, and sociobehavioral research integration.
Conclusions:
- Updated recommendations provide a framework for safer, more effective ATI studies.
- These revised guidelines will facilitate advancements in the pursuit of an HIV cure.
- The updated protocols aim to balance scientific rigor with participant well-being and ethical considerations.
More Related Videos
Related Concept Videos
Retrovirus Life Cycles
Therapeutic Drug Monitoring: Affecting Factors
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Clinical Trials: Overview
Comparing the Survival Analysis of Two or More Groups

